NFL Picks for PFT Week 6 2025: Florio vs. Simms

Last week was a mess. This week can’t get much worse.

I was 4-10 years straight. Four and ten! The gap worked a little better, at 6-8.

Simms and I disagreed over six games. He hit five, to go 8-6. My lead imploded from nine games to two.

For the year, I’m 51-26-1 and 44-34 ATS. Simms is 49-28-1 and 39-39.

This week we only differ in one match, live and against the spread.

I always say this about betting: “Please bet responsibly, only with money you can afford to lose. Because if you listen to an idiot like me, you will.” This has never been more true than last week.

For this week’s latest disaster in the making, scroll down.

Eagles (-7) at the Giants

Can the Eagles figure out their offense in a short week? If not now, when?

Florio’s pick: Eagles 24, Giants 13.

Simms’ pick: Eagles 27, Giants 17.

Broncos (-7.5) vs. Jets in London

The Broncos have a chance to start collecting wins, starting with a team that can’t stop racking up losses.

Florio’s pick: Broncos 28, Jets 9.

Simms’ pick: Broncos 28, Jets 13.

Rams (-7.5) at Ravens

The Ravens’ mood went from “not our day” to “not our year.”

Florio’s pick: Rams 30, Ravens 13.

Simms’ pick: Rams 34, Ravens 17.

Cowboys (-3) at Panthers

The Cowboys continue to claw their way into the race.

Florio’s pick: Cowboys 27, Panthers 20.

Simms’ pick: Cowboys 31, Panthers 27.

Cardinals at Colts (-7)

One thing is certain: neither team will let a player drop the ball before the goal line. Again.

Florio’s pick: Colts 27, Cardinals 17.

Simms’ pick: Colts 31, Cardinals 20.

Seahawks vs. Jaguars (-1.5)

The Jaguars are real. Real enough to beat a team that has become virtually unbeatable on the road.

Florio’s pick: Jaguars 21, Seahawks 17.

Simms’ pick: Jaguars 34, Seahawks 24.

Chargers (-4.5) at the Dolphins

If the Chargers didn’t have so many injuries, this one would be a real blowout.

Florio’s pick: Chargers 27, Dolphins 24.

Simms’ pick: Chargers 23, Dolphins 20.

Patriots (-3.5) at the Saints

A playoff run looms for the Pats.

Florio’s pick: Patriots 24, Saints 16.

Simms’ pick: Patriots 28, Saints 17.

Browns at Steelers (-5.5)

Aaron Rodgers against a rookie? Sorry, Browns.

Florio’s pick: Steelers 24, Browns 14.

Simms’ pick: Steelers 20, Browns 13.

Titans vs. Raiders (-3.5)

Tom Brady might want a refund.

Florio’s pick: Raiders 28, Titans 24.

Simms’ pick: Raiders 20, Titans 13.

Bengals at Packers (-14)

Different quarterback, same result.

Florio’s pick: Packers 34, Bengals 17.

Simms’ pick: Packers 35, Bengals 20.

49ers at Buccaneers (-3)

The Bucs arrived in the Super Bowl window.

Florio’s pick: Buccaneers 31, 49ers 27.

Simms’ pick: Buccaneers 24, 49ers 20.

Lions at the Chiefs (-2.5)

Why are the Chiefs favored?

Florio’s pick: Lions 30, Chiefs 24.

Simms’ pick: Lions 30, Chiefs 21.

Bills (-4.5) for the Falcons

The Bills are vulnerable to another upset.

Florio’s pick: Bills 23, Falcons 20.

Simms’ pick: Bills 24, Falcons 21.

Bear among commanders (-4.5)

Forget last year’s Hail Mary debacle. This one is a rematch of the Commanders-Lions playoff game in which Dan Quinn beat Ben Johnson.

Florio’s pick: Commanders 35, Bears 27.

Simms’ pick: Bears 34, Commanders 31.