Health. Will we soon be able to detect Alzheimer’s disease in advance?

Early diagnosis of Alzheimer’s disease is one of the challenges of research. However, even today, 1 patient out of 2 is unaware that he has the disease and will only learn of it at an advanced stage. “Thus, nearly half a million people do not benefit from appropriate care in France”explains the Vaincre Alzheimer Foundation.

One of the main causes of Alzheimer’s disease is the buildup of beta-amyloid protein in the brain, where it forms plaques. Scientists from Hokkaido University and Toppan have managed to develop technology capable of spotting this accumulation.

Their blood test actually detects certain biomarkers (beta-amyloid binding exosomes), which increase as beta-amyloid proteins accumulate in the brain. An advance which for the moment has proven itself… on the mouse.

In addition to the lack of effective treatments for Alzheimer’s disease, there are few methods to diagnose it. “, note the authors. ” This pathology can only be definitively diagnosed by a direct examination of the brain through an autopsy. Beta-amyloid buildup in the brain can be measured by cerebrospinal fluid tests or positron emission tomography. However, the first test is extremely invasive, and the second is quite expensive. Thus, there is a need for a diagnostic test which is both economical, accurate and widely available. »

In addition, an early diagnosis would make it possible to set up a treatment as soon as possible, whether medicinal or not (cognitive stimulation, psychological care, speech therapy, etc.).

Source: Alzheimer’s Research & Therapy.


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